New Sensor for Folic Acid and Antineoplastic Folates

  • Author: ChemViews
  • Published Date: 09 October 2011
  • Source / Publisher: European Journal of Organic Chemistry/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: New Sensor for Folic Acid and Antineoplastic Folates

Related Societies

The recognition and sensing of anionic substrates by positively charged or neutral synthetic receptors has attracted considerable attention during the last decade because of the fundamental role that anions play in many chemical and biological processes. For instance, folic acid and folate anions have been implicated in cardiovascular diseases, neural tube defects, and certain kinds of cancer. The study of bioanalytes in urine, blood, or saliva are generally carried out in water and sensors are required to detect anions in these conditions.

Jeroni Morey and colleagues, University of Illes Balears, Spain, have reported tripodal, squaramido-based receptors (pictured) capable of tight binding of folate anions. These are the first abiotic receptors that employ a noncovalent ammonium–carboxylate electrostatic interaction and a hydrogen bond to achieve high-affinity molecular recognition in water.

Receptor for folates

The new receptor allowed quantitative determination of folic acid and folate-like antineoplastic agents, such as methotrexate, through addition of the fluorescence indicator 5-carboxyfluorescein. This method is cheaper, quicker, and simpler than existing methods, which means it could be an excellent method for the routine determination of quantities of folic acid and methotrexate.

Images: © Wiley-VCH

Article Views: 2878

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH