Golden Bullets for Cancer

Golden Bullets for Cancer

Author: Jonathan Faiz

Alkynyl phosphine gold complexes have potential as chemotherapeutics. A team of researchers from Germany and The Netherlands led by Ingo Ott, Technische Universität Braunschweig, Germany, prepared a series of six alkynyl gold(I) complexes and used them in biological assays. Proliferation assays showed the IC50 values of the complexes to be comparable with cytostatics such as cisplatin and 5-fluorouracil. According to an independent referee, these complexes comprise a promising new class of bioorganometallic anticancer drug candidates.

The compounds also act as thioredoxin reductase inhibitors, and have a significant effect on blood vessel formation in zebrafish embryos (pictured). Further investigations planned by the authors include the identification of further targets and the development of structure–activity relationships.


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