Peptidodendrimer Drug Delivery

  • Author: Evenda Dench
  • Published Date: 15 September 2012
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Peptidodendrimer Drug Delivery

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A peptidodendrimeric scaffold that has the potential to be used as a cellular delivery platform has been developed by Marcus Weck, Stefania Galdiero, and colleagues, New York University, USA, and Università di Napoli, Italy. The dendrimer is able to enter cells due to the attachment of the membrane-interacting gH625 peptide at the termini.

The peptide is able to form a transient helical structure that temporarily affects membrane organization, facilitating insertion into the membrane by a passive translocation mechanism. This allows the cargo to be released directly into the intracellular matrix as opposed to being trapped in endosomes, from which the cargo might not be able to escape before lysosomal degradation.

This peptidodendrimeric scaffold may be a useful delivery vehicle for therapeutics.

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Rajendra Kurapati wrote:

nice work

ncie to see Peptidodendrimers.

Tue Sep 18 05:48:08 UTC 2012

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Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH