First Nanoparticles Targeting Senescent Cells

  • Author: Jonathan Faiz
  • Published Date: 11 October 2012
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: First Nanoparticles Targeting Senescent Cells

Spanish researchers have prepared microporous silica nanoparticles capped with galacto-oligosaccharides as a cargo release system specific for senescent cells. These are cells with an altered phenotype that are not completely destroyed by the immune system and thus accumulate in tissue over time. The strategy reported by Ramón Martínez-Máñez, University of Valencia, Rosario Perona, Institute for Biomedical Research, Madrid, José Ramón Murguía, Joint Institute of Molecular and Cell Biology of Plants, Valencia, and their respective co-workers allows senescent cells to be targeted as the galacto-oligosaccharide caps are a substrate of senescence-associated β-galactosidase.

In the presence of senescent cells, the enzyme hydrolyzes the cap, thus releasing the cargo. The researchers used Rhodamine B as a model drug and studied its release in both in vitro and in vivo experiments. The nanoparticles were internalized in all cell types studied, but released their cargo only in β-galactosidase overexpressing cells.

This is the first example of the selective targeting of senescent cells with nanoparticles and may become an effective strategy in the treatment of age-related diseases.

Article Views: 5464

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permisson guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH