Answer to the Quiz: A Modern Synthesis of Strychnine
The authors prepared strychnine using the following reaction sequence:
The synthesis was taken from the publication below.
- A Novel and General Synthetic Pathway to Strychnos Indole Alkaloids: Total Syntheses of (−)-Tubifoline, (−)-Dehydrotubifoline, and (−)-Strychnine Using Palladium-Catalyzed Asymmetric Allylic Substitution,
M. Mori, M. Nakanishi, D. Kajishima, Y. Sato,
J. Am. Chem. Soc. 2003, 125 (32), 9801–9807.