A Full Stack with Protein Amides

  • Author: Scott Williams
  • Published Date: 05 February 2013
  • Source / Publisher: ChemMedChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: A Full Stack with Protein Amides

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π-Stacking plays an important role in protein–ligand binding. In contrast to the aromatic–aromatic stacking of phenyl or heteroaryl rings, interactions with protein amide π systems, with their large dipole moments, is less well understood. By complementing quantum chemical calculations with data mining in experimental protein X-ray structure databases, Michael Harder, François Diederich, ETH Zurich, and Bernd Kuhn, F. Hoffmann–La Roche, both Switzerland, investigated the geometric preferences and energetics of π stacking of various heteroarenes on planar protein amide fragments. The results are relevant for structure-based drug design, as the less polar π surface of protein amides is accessible for ligand interaction in many binding sites, either as part of the protein backbone or in Gln/Asn side chains.


The authors derived some practical guidelines for rational drug design: such interactions depend heavily on the relative orientation and magnitude of the interacting dipole vectors, and less on the ideal alignment of partial charges; moreover, the π-electron density of the heteroarene correlates with binding strength. These results will help chemists establish better protein–ligand interactions through structure-based design and should also inspire further studies to explain stacking interactions between protein amide groups and (hetero)arenes.


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