Light Controlled Insulin Release

  • Author: Melania Tesio
  • Published Date: 11 February 2013
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Light Controlled Insulin Release

Insulin is a pancreatic hormone which regulates the carbohydrate metabolism by stimulating the uptake of glucose from the blood circulation. Its pathological absence or its malfunctioning cause metabolic diseases, such as diabetes. These conditions are treated with exogenous insulin, which needs to be injected multiple times per day, thus representing a burden for the patients.

Piyush Jain and colleagues, University of Missouri, USA, developed a system to improve the delivery of this hormone. The researchers modified insulin by introducing 1-(4,5-dimethoxy-2-nitrophenyl)ethyl (DMNPE)-azide moieties and covalently attached the modified insulin to a rink amide poly(ethylene glycol) resin via a photocleavable linker. In doing so, the scientists obtained a subcutaneous, photoactivated insulin depot which releases the hormone when illuminated with a light-emitting diode.

Although this system can be further optimized using a biodegradable resin, it can efficiently deliver insulin at appropriate times and amounts.

Article Views: 3867

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH