Guinness Molecules: Identifying Lowest-Energy Structures

  • Author: Jonathan Faiz
  • Published Date: 07 December 2013
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Guinness Molecules: Identifying Lowest-Energy Structures

What is the most stable structure of the molecule with the sum formula C6H12O6?
Glucose is the first molecule that comes to mind, but this is certainly not the most stable. Identifying the lowest-energy structure for a certain sum formula, or "Guinness molecule", is important in the areas of chemical energy conversion, astrophysics, or even fermentation.

In his Editorial in Angewandte Chemie, Martin A. Suhm, Göttingen University, Germany, discusses some Guinness molecules. Some structures like H2O are straightforward. For carbohydrates (CH2O)n, formalydehyde may seem the obvious Guinness molecule, when n = 1. In fact, when zero-point energy is taken into account, the van der Waals complex between H2 and CO is the winner. For n = 2, the complex between methane and carbon dioxide is more stable than CH3COOH, which in turn is more stable than HOCH2−CHO. This could explain the low abundance of acetic acid in space.

The search for Guinness molecules takes into account subjects such as quantum mechanics and spectroscopy and thus is a highly useful teaching tool for helping students think about relative bond strengths.

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