Detecting Copper a Turn-On

  • ChemPubSoc Europe Logo
  • Author: Asian Journal of Organic Chemistry
  • Published Date: 17 March 2014
  • Source / Publisher: Asian Journal of Organic Chemistry/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Detecting Copper a Turn-On

As one of most abundant essential trace elements in the human body, copper plays a critical role as a catalytic cofactor for a variety of metalloenzymes. However, a relatively high level of copper in the body can cause liver or kidney damage. Although a number of fluorescent Cu2+ sensors have been reported, the selectivity for Cu2+ over other metals ions, such as Fe3+ or Pb2+, is not very satisfactory. In addition, most traditional probes to sense Cu2+ through a “turn-off” mechanism due to the paramagnetic nature of Cu2+ ions are not practical. Therefore, developing a method for highly selective and sensitive detection of copper is necessary through a “turn-on” response is desirable.


Qichun Zhang and co-workers from Nanyang Technological University, Singapore, have developed the “turn-on” Cu2+ chemosensor 1,2,5,6-tetra(5-hexylthiophene-2-yl)-hexaazapentacene (4HP) through a one-step cyclocondensation. The binding behavior of 4HP toward various cations demonstrated a selective and sensitive response towards Cu2+ ions. The detection limit is 1.2 µM in DMF solution. The group hopes that the work will provide a blueprint for future development of metal-ion sensors.


Article Views: 3678

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH