What's Bugging the Bees?

  • Author: ChemBioChem
  • Published Date: 31 July 2014
  • Source / Publisher: ChemBioChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: What's Bugging the Bees?

Related Societies

Over the past decade, a sharp decline in worldwide honey bee population has been well documented. One of the causes of this population decrease has been the notorious bacterial honey bee pathogen, Paenibacillus larvae.

A consortium of German microbiologists and natural-product chemists, lead by Rolf Müller at the Helmholtz Centre of Infection Research and the Helmholtz Institute for Pharmaceutical Research, has discovered a group of antibiotic lipopeptides from cultures of P. larvae, for which the trivial names Paenilarvins is proposed. The paenilarvins belong to the iturin family and exhibited strong anti-fungal effects, as well as significant toxicity against honey bee larvae upon oral administration.

Paenilarvins are products of a non-ribosomal peptide synthetase (NRPS)/polketide synthase (PKS) hybrid gene cluster, which was predicted from a genome-mining analysis of the P. larvae genotype. Several other gene clusters putatively encoding for NRPS/PKS metabolites were also found but their products remain widely uncharacterized.

Recent genome-mining projects have revealed entomopathogenic bacteria with great potential for the production of new secondary metabolites. In nature, these compounds may act as, for example, virulence factors, means of defense against competing pathogens that are associated with the same host, or as signaling and regulatory molecules. However, these secondary metabolites are often not easily produced using standard laboratory methods. Future development of optimal growth and production conditions will allow for isolation of these compounds in sufficient quantities for their structure elucidation and biological characterization.


Also of interest:

Article Views: 3898

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH