In this issue, H. J. Schneider et al. revisit the hydrophobic effect in a Review. What roles do water molecules in cavities play? In a Minireview, H. Waldmann et al. discuss asymmetric hetero-Diels–Alder reactions. D. A. Evans reveals the history of ChemDraw in an Essay. The Highlights deal with a stable binary carbon(IV) nitride (E. Kroke) and iron in methane activation (M. Ruitenbeek and B. M. Weckhuysen). In his Editorial, J. F. Stoddart reflects on the options of putting mechanically interlocked molecules to work into tomorrow’s world.

In the Communications section, T. Iwamoto et al. present persistent antimony- and bismuth-centered radicals in solution (see picture). P. Nagorny et al. succeeded in the enantioselective synthesis of piperidines via chiral mixed phosphoric acid acetals. F. Weinhold and R. A. Klein describe anti-electrostatic hydrogen bonds, and S. Han et al. report on the surface-drying properties of bioadhesive proteins.

• Angewandte Chemie 42/2014: Highly Selective,
  Angew. Chem. Int. Ed. 2014, 42.