'Oh No!' to ONOO-

  • Author: Emma Scales
  • Published Date: 08 June 2010
  • Source / Publisher: Chem. Eur. J./Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: 'Oh No!' to ONOO<sup>-</sup>

Related Societies

Peroxynitrite (ONOO-), a short-lived reactive oxygen species, has attracted much attention because it can cause serious damage to living systems. It is generated in biological systems through the spontaneous coupling reaction of nitric oxide (NO) and superoxide radical (O2•-). This peroxide in itself is very reactive; however, its biological action is particularly notorious under elevated cell/tissue rates of NO and/or O2•- production.


Increasing evidence has shown that aberrant ONOO- activities may contribute to a series of human diseases including inflammatory processes, ischemic reperfusion injury, multiple sclerosis, stroke, cancer, and neurodegenerative disorders.


J. Yuan, Y. Guan et al. from the Dalian Institute of Chemical Physics at the Chinese Academy of Sciences (China) have designed and synthesized a unique lanthanide-complex-based ratiometric luminescence probe specific for peroxynitrite. The new probe with fine ratiometric and time-gated capacities provides a novel strategy for the luminescent imaging detection of ONOO- in living cells.


Article Views: 3233

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH