Super Supramolecular Adducts

Super Supramolecular Adducts

Author: Emma Scales

To design efficient targeting strategies in magnetic resonance (MR) molecular imaging applications, Silvio Aime et al. from the Unviersity of Milan, Italy, explored the formation of supramolecular adducts between (strept)avidin ((S)Av) and tribiotinylated Gd-DOTA-monoamide complexes (DOTA = 1,4,7,10-tetraazacyclododecane-N,N’,N”,N”‘-tetraacetic acid).

One of these systems, endowed with high relaxivity, allowed the MRI visualization of Kaposi’s sarcoma cells and tumor endothelial cells.


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