Back to the Murraya Roots

  • Author: Anne Deveson
  • Published Date: 29 April 2015
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Back to the Murraya Roots

Related Societies

Murrayamines-O and -P are two novel pentacyclic alkaloids isolated from plants of genus Murraya – flowering plants that have been used in traditional medicine for the treatment of fever, pain, diabetics, dysentery, painful inflammatory conditions, to induce labor and for cancer treatments.

Dattatraya H. Dethe and colleagues, Indian Institute of Technology, Kanpur, have succeeded in the first enantiospecific total syntheses of the cannabinol-skeletal carbazole alkaloids murrayamines-O and -P (pictured). Synthesis of both natural products and their enantiomers were achieved in a highly atom economical and protecting-group free manner on the gram scale. The synthesis has a six steps longest linear sequence starting from (–)-(S)- and (+)-(R)-cis-verbenol.

This expands the number of natural products isolated that belong to this family of biologically active compounds to well over fifty.


Article Views: 2366

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH