Programmed Destruction

  • Author: Emma Scales
  • Published Date: 07 August 2010
  • Source / Publisher: Chemistry - A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Programmed Destruction

Various human diseases, including different types of cancer, are associated with a disturbed intracellular redox balance and oxidative stress (OS). The past decade has witnessed the emergence of redox-modulating compounds able to utilize such pre-existing disturbances in the redox state of sick cells for therapeutic advantage.

Claus Jacob et al. from Saarland University, Saarbr├╝cken, Germany, describe selenium- and tellurium-based agents that can turn the oxidizing redox environment present in certain cancer cells into a lethal cocktail of reactive species, which pushes these cells over a critical redox threshold and ultimately kills them through apoptosis. This kind of toxicity is highly selective: normal, healthy cells remain largely unaffected because changes to their naturally low levels of oxidizing species produce little effect.

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Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH