Heme not Required

Heme not Required

Author: Rosalyne Cowie

Until now, no intermediates have been observed in C–H oxidations with hydrogen peroxide catalyzed by iron complexes.

Elena Rybak-Akimova and Olga Makhlynets, Medford MA, USA, have performed detailed kinetic and mechanistic studies on oxidations with hydrogen peroxide catalyzed by [Fe(bpmen)(CH3CN)2][ClO4]2 (bpmen=N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)ethane-1,2-diamine).

It was found that that FeIII(OOH) produces the reactive oxidant in the rate-limiting, acid-assisted heterolytic cleavage of the O


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