Cancer Ablation with Organic Nanoparticles

Cancer Ablation with Organic Nanoparticles

Author: ChemViews

Photothermal nanomaterials have the potential to treat cancer, either through the controlled delivery and release of chemotherapeutic drugs, or by targeting the tumor region with a laser-guided light source without surgical intervention.

Yong-Min Huh, Seungjoo Haam and colleagues, Yonsei University, Republic of Korea, have developed polyaniline-based nanoparticles (PANPs) for the thermal ablation of cancer cells. The PANPs took two forms: the emeralidine base and its salt. Switching between the two could be achieved by doping with phosphate-buffered saline or with biological dopants such as protons or other oxidative species present in the intracellular environment.

Formation of the emeralidine salt shifted the optical-absorbance peak toward the near-IR region. This generated a substantial amount of heat energy that could be used to kill cancer-cells without damaging surrounding tissue.


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