In this issue, W.-j. Chung and C. D. Vanderwal review stereoselective halogenations in natural product syntheses. How have organic chemists dealt with the associated challenges? J. Waser et al. review the use of cyclic hypervalent reagents for atom-transfer reactions. How was the scope of this type of reaction extended beyond trifluoromethylation? In his Editorial, U. Bornscheuer discusses how biocatalysis successfully crosses boundaries.

In the Communications section, L. Liu et al. present total syntheses of three tetracyclic diterpenes (see picture). A. J. Welch et al. show how carborane substituents promote direct electrophilic insertion over reduction–metalation reactions. I. A. Weinstock et al. describe the uptake and assembly of alkanes within porous nanocapsules in water, and the role of hydrophobic confinement.

• Angewandte Chemie 14/2016: Crossing Boundaries,
  Angew. Chem. Int. Ed. 2016, 55 (14).