Assembling Cells with Magnets

  • Author: ChemistryViews.org
  • Published: 11 November 2016
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: ACS Biomaterials Science & Engineering/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Assembling Cells with Magnets

Cultured cells usually grow in monolayers. However, three-dimensional cell assemblies can better simulate physiological conditions. Ishwar K. Puri, McMaster University, Hamilton, ON, Canada, and colleagues have developed the first contactless and label-free process to manipulate the 3D shape of cell assemblies on a macro scale. They used the difference in magnetic properties between diamagnetic red blood cells and a paramagnetic surrounding to achieve this effect.


The team placed neodymium magnets in different configurations around a vial containing human whole blood in a paramagnetic solution of gadopentatic acid (Gd-DTPA) in phosphate-buffered saline (PBS). They were able to generate cell assemblies in the shape of rectangles, stars, and spheroids. The difference in magnetic susceptibility of the cells and the surrounding solution causes the cells to move in the fluid and assemble in regions of lower magnetic field strength.


The process does not require nozzles, which are often used to create 3D cell structures but can cause contamination. According to the researchers, their contactless method for creating 3D cell assemblies could improve tissue engineering, cell-on-chip devices, and drug screening.


 

Article Views: 1469

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH