Mesoporous Silica with Extra-Large Pores

  • Author: Georg R. Meseck
  • Published: 03 May 2017
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Nano Letters/ACS Publications
thumbnail image: Mesoporous Silica with Extra-Large Pores

Mesoporous silica nanoparticles (MSNs) have been investigated as drug delivery vessels because of their high surface area, large pore volume, and the possibility of surface functionalization. Made by soft-templating of surfactant micelles or block co-polymers, the pores of these MSNs typically have sizes of a few nanometers. This pore size has proven successful for the delivery of small molecules. However, materials with larger pores are required to extend this drug delivery technique to large therapeutic biomolecules.


Jaeyun Kim, Sungkyunkwan University, Suwon, Suk-Jo Kang, Korea Advanced Institute of Science and Technology, Daejon, both Republic of Korea (KAIST), and colleagues have developed a synthesis route to MSNs with extra-large pores. The team used cetyltrimethylammonium bromide (CTAB)-stabilized iron oxide nanoparticles as seeds in a sol-gel process. In the presence of high amounts of ethyl acetate as an additive, uniform MSNs with pores in the range of 30 nm were formed. The diameter of the particles could be tuned from 100 nm to 180 nm.


The synthesized particles could be loaded with higher levels of IL-4 (an anti-inflammatory cytokine) than particles with small pores. The researchers showed that the IL-4-loaded particles were successfully delivered to macrophages, where they induced an anti-inflammatory response.


 

Article Views: 1861

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH