Practical Synthesis of α-Substituted Primary Benzylamines

  • Author:
  • Published: 21 December 2018
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Organic Letters/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Practical Synthesis of α-Substituted Primary Benzylamines

α-Substituted benzylamines can be found in a variety of biologically active compounds. Usually, functionalized benzyl derivatives are required for the formation of the C–N bond during the synthesis of this type of molecule. The existing direct routes to primary amines usually afford only protected amines and require further steps to obtain the desired product.

Søren Kramer, Technical University of Denmark, Lyngby, has developed a direct synthesis of α-substituted primary benzylamines from alkylarenes and diarylimines. The reaction directly gives the desired amines as their hydrochloride salts (pictured). The alkylarenes were combined with benzophenone imine using CuI as a catalyst, 1,10-phenanthroline as a ligand, (tBuO)2 as a stable peroxide, and chlorobenzene as the solvent.

The desired unprotected amines were obtained in good yields. The catalyst system is simple and can be used in low concentrations. The reaction tolerates both air and moisture. Overall, the protocol is a practical, fast path to primary benzylamine building blocks.


Article Views: 923

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

CONNECT: on Facebook on Twitter on YouTube on LinkedIn Sign up for our free newsletter

A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH