Molecular Remodeling

Molecular Remodeling

Author: ChemistryViews

A diverse library of compounds for pharmaceutical screening can be created starting with a single reactive natural product, according to US chemists.

Researchers at Boston University started with the highly oxygenated natural product fumagillol to create a diverse compound library for physiological screening. The team used a reaction-based approach to remodel the original compound in several different ways. For instance, reactions with amines occur with excellent regiocontrol to form epoxide opening/cyclization sequences to give perhydroisoindole or perhydroisoquinoline products. These intermediates can themselves be remodelled using a cascade of reactions to generate morpholinone or bridged 4,1-benzoxazepine derivatives.


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