Bacteria Trigger Multiple Sclerosis

  • Author: ChemistryViews
  • Published: 31 October 2011
  • Copyright: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Nature
thumbnail image: Bacteria Trigger Multiple Sclerosis

According to scientists from the Max Planck Institute of Neurobiology in Martinsried, Germany, not harmful but beneficial bacteria of the natural intestinal flora, which every human being needs for digestion, trigger multiple sclerosis.

The likelihood of developing multiple sclerosis, a disease in which proteins on the surface of the myelin layer in the brain activate the immune system, is influenced by genes and environmental factors. The latter have an even greater impact on the disease’s development. Scientists have long suspected that it is caused by infectious agents.

The team around Gurumoorthy Krishnamoorthy discovered that genetically modified mice in the absence of exposure to any external influences, develop an inflammation in the brain similar to the human disease if they have normal bacterial intestinal flora. The microorganisms begin by activating the immune system’s T cells and, in a further step, the B immune cells.

The findings suggest that in humans with the corresponding genetic predisposition, the essentially beneficial intestinal flora could act as a trigger for the development of multiple sclerosis. Precisely which bacteria are involved remains unclear.

Article Views: 1969

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

CONNECT: on Facebook on Twitter on YouTube on LinkedIn Sign up for our free newsletter

Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH