Source of Psychedelic Action of Mushrooms

  • Author: David Bradley
  • Published: 12 February 2012
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Proceedings of the National Academy of Sciences/National Academy of Sciences
thumbnail image: Source of Psychedelic Action of Mushrooms

Researchers led by David Nutt, University of Bristol, UK, have homed in on a mode of action of psilocybin, a classic psychedelic found in magic mushrooms. Psilocybin is quickly converted by the body to psilocin, which has mind-altering effects similar to those of LSD and mescaline.

The UK team has shown using functional magnetic resonance imaging (fMRI) that a component of Psilocybe cubensis and other species of magic mushrooms that is first metabolized to psilocin, appears to decrease brain "connectivity". Experiments involving pre-treatment with antagonists for the 5-HT2A receptor and tests with knock-out mice lacking the gene for this protein allowed the researchers to show that this receptor, which belongs to the serotonin receptor family, is the source of the psychedelic action of "shrooms".

Article Views: 2614

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH