Nano Magnets Enter the Brain

  • Author: David Bradley
  • Published: 04 April 2012
  • Copyright: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: ACSNano/ACS
thumbnail image: Nano Magnets Enter the Brain

Magnetic nanoparticles comprising poly(ethylene glycol) (PEG) coatediron(II,III) oxide particles, commonly known as magnetite, conjugated to lactoferrin (Lf) have been shown to cross the blood-brain barrier. The receptor-mediated delivery system was developed by collaborators at the Chinese Academy of Sciences, Sichuan University and Westfälische Wilhelms-Universität in Germany. The efficacy of the delivery method has been tested in laboratory rats as demonstrated by magnetic resonance imaging.

The technology could allow the targeted delivery of imaging tools as well as pharmaceutical agents direct to the brain, according to the team.

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