Limonoid Extracts Give New Natural Products

  • Author: David Bradley
  • Published: 04 September 2012
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Tetrahedron Letters/Elsevier
thumbnail image: Limonoid Extracts Give New Natural Products

Two new limonoids, malayanines A and B, were identified by researchers at the University of Malaya, Kuala Lumpur, Malaysia, and their colleagues in France. The new limonoids were isolated from the bark of the tree Chisocheton erythrocarpus. Other limonoids include azadirachtin, walsogyne A, and the velutabularins compounds with demonstrable anticancer, antimalarial and insecticidal properties.


The complex skeleton of the limonoids contains a furanolactone group connected to several five- or six-membered carbon rings and always represents an intriguing target for synthetic organic chemists. The same team previously identified erythrocarpine E from the same tree. This is a limonoid that can trigger programmed cell death, apoptosis in cells. However, the newly discovered malayanines A and B contain previously unseen tetrahydropyran-2-ol and tetrahyrofuran-2-ol substructures, respectively, within their tetranortriterpenoid core offering attractive molecular diversity and new potential activities.


Article Views: 2327

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH