Improving Drug Delivery to the Brain

  • Author: Melania Tesio
  • Published: 20 September 2012
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Proceedings of the National Academy of Sciences/National Academy of Sciences
thumbnail image: Improving Drug Delivery to the Brain

The blood-brain barrier separates the blood from the extracellular fluids of the brain. It consists of a capillary endothelium endowed with drug efflux pumps such as P-glycoprotein. By transporting compounds out of the brain, this molecule represents a major obstacle to deliver therapeutic drugs to this organ.


Ronald E. Cannon, National Institute of Health, USA, and colleagues identified a signaling pathway which can pharmacologically target P-glycoprotein. The scientists discovered that the activity of the pump is reduced by the sphingolipid sphingosine-1-phosphate (S1P). As a consequence, when they delivered to rats S1P or its therapeutic analogs (FTY720 and FTY720P), they could rapidly and reversibly inhibit P-glycoprotein and, therefore, increase the uptake of the transporter’s substrates.


Sphingolipid-based drugs could, therefore, be useful to improve drug delivery across the blood brain barrier.


Article Views: 2103

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH