Cryptophane Proves Good Host

  • Author: Vikki Cantrill
  • Published: 31 May 2013
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Organic Letters/ACS Publications
thumbnail image: Cryptophane Proves Good Host

Laser-polarized 129Xe NMR spectroscopy is a very attractive tool for magnetic resonance imaging (MRI). Xenon is a nontoxic gas, soluble in biological fluids, and readily delivered by inhalation. The enhanced NMR signal also means small quantities of the gas can be easily detected. However, xenon is not selective and so biosensors, able to encapsulate xenon and bind to a specific target, are particularly attractive.


Bernard Rousseau and colleagues, Commissariat à l’énergie atomique et aux énergies alternatives, France, have synthesized a functionalized molecular cage that could be modified to recognize a specific biological target. Based on cryptophane-111 (pictured), the cavity has a high affinity for xenon in both organic solvents and water. Synthesized in three steps from cryptophane-111, this cage could be further derivatized to form specific bioprobes.
The researchers now aim to graft the cage onto various biomolecules through amide bond forming reactions.


Article Views: 2861

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH