DNA Encapsulated Enzymes

DNA Encapsulated Enzymes

Author: Veronika Belusa

Chun Geng and Paul J. Paukstelis, University of Maryland, USA, used bovine RNase A as a model enzyme to show that enzymes captured in solvent channels of a DNA crystal are catalytically active. The encapsulated enzyme can break the phosphodiester linkage of a quenched fluorescent rUA dinucleotide that containes 5′-dabcyl and 3′-fluorescein moieties with similar kinetic restriction as other immobilized enzyme systems.

This finding opens possibilities for developing modular solid-state catalysts that could be both, biocompatible and biodegradable.

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