Solid Approach to Product Extraction

  • Author: Vikki Cantrill
  • Published: 14 October 2014
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Organic Letters/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Solid Approach to Product Extraction

The compound discovery stage for many pharmaceuticals, agrochemicals, and materials often requires the synthesis of a large number of compounds in relatively small amounts (milligram to gram scale). Although the synthesis of libraries of organic compounds can be automated, the workup of these reactions is frequently time consuming. Often a liquid-liquid extraction is followed by column chromatography.

A faster technique has been developed by Bo Xu and Gerald Hammond, Rigid Solutions, LLC, Shelbyville, KY, USA, and the University of Louisville, KY, USA. Instead of a conventional workup, a porous honeycomb-like organic polymer (Porelite) is added to the reaction mixture (≈ 3 mL/g of product). Porelite absorbs the product and the organic solvent in which it is dissolved. This high internal phase emulsion polymer contains extremely large cavities interconnected by smaller pores that allow the product in and out. The loaded polymer is then simply filtered and washed before elution of products or loading onto a chromatographic column.

In tests, excellent recovery rates were obtained for hydrocarbons, phenols, heterocycles, acids, and bases. This general technique lends itself to parallel and automated operations.


Article Views: 3507

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH