Making Cisplatin with Microwaves

  • Author: Xin Su
  • Published: 19 January 2015
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Dalton Transactions/Royal Society of Chemistry (RSC)
  • Associated Societies: Royal Society of Chemistry (RSC), UK
thumbnail image: Making Cisplatin with Microwaves

Cisplatin, or cis-diamminedichloroplatinum(II) (cis-[Pt(NH3)2Cl2]), is a well-known anticancer drug used in chemotherapy. While its synthesis has been well optimized, the best route still involves multiple steps and takes two to three hours.


Using microwave-enhanced synthesis, James D. Hoeschele and co-workers, Eastern Michigan University, Ypsilanti, MI, USA, considerably shorten the time of a classic one-step preparation for cisplatin. By heating K2PtCl4, NH4OAc, and KCl in a 1:4:2 molar ratio at 100 °C, the new procedure gives purified product in 47 % yield within only 80 minutes. This new synthesis, given the very short time it takes, is especially ideal for incorporating the short-lived radioactive 195mPt into cisplatin, which provides a longer effective lifetime for biological studies.


 

Article Views: 2573

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH