Making Cisplatin with Microwaves

  • Author: Xin Su
  • Published: 19 January 2015
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Dalton Transactions/Royal Society of Chemistry (RSC)
  • Associated Societies: Royal Society of Chemistry (RSC), UK
thumbnail image: Making Cisplatin with Microwaves

Cisplatin, or cis-diamminedichloroplatinum(II) (cis-[Pt(NH3)2Cl2]), is a well-known anticancer drug used in chemotherapy. While its synthesis has been well optimized, the best route still involves multiple steps and takes two to three hours.

Using microwave-enhanced synthesis, James D. Hoeschele and co-workers, Eastern Michigan University, Ypsilanti, MI, USA, considerably shorten the time of a classic one-step preparation for cisplatin. By heating K2PtCl4, NH4OAc, and KCl in a 1:4:2 molar ratio at 100 °C, the new procedure gives purified product in 47 % yield within only 80 minutes. This new synthesis, given the very short time it takes, is especially ideal for incorporating the short-lived radioactive 195mPt into cisplatin, which provides a longer effective lifetime for biological studies.


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