The CuH-catalyzed stereodivergent hydroamination through asymmetric desymmetrization of cyclobutenes has been achieved, yielding a range of trisubstituted aminocyclobutanes with excellent results. A series of subsequent transformations, including the first asymmetric synthesis of two pharmaceutically active molecules, have been realized, and density functional theory calculations have been employed to illustrate the origin of the stereodivergence of the reaction.

[Research Article]
Xiang Lei, Peng Luo, Shouang Lan, Wennan Dong, Chao Xu, Jinggong Liu, Shuang Yang, Qi Zhang, Xinqiang Fang
ChemistryEurope, https://doi.org/10.1002/ceur.202500325. Read article.

High energy Ni-rich cathodes face lattice distortion and surface collapse during operation. Traditional high-valence doping stabilizes surface but not bulk due to dopant segregation. This work introduces a slightly Li-rich lattice to enable uniform Mo6+ bulk doping via specially designed molten-salt synthesis. The bulk-strengthened cathode exhibits outstanding electrochemical performance and stability in both liquid and all-solid-state batteries.

[Research Article]
Xiaoqiao Li, Fanxiu Feng, Taiping Hu, Yong Wang, Chenji Hu, Jingyu Chen, Yilin Chen, Chun Cheng, Han Wang, Qinfeng Zheng, Yixiao Zhang, Yu-Shi He, Shenzhen Xu, Wei Zhang, Liwei Chen, Zi-Feng Ma, Linsen Li
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202512729. Read article.

Soft-hard multiphase hydrogels have been constructed using hydrogen-bonded organic frameworks and polymerized deep eutectic solvent, the multiple noncovalent interactions facilitate the energy dissipation and ion transport, leading to remarkable strength, toughness and ionic conductivity. They could be used as strain sensors for health monitoring and gesture-to-recognition translation.

[Research Article]
Guohui Liu, Dr. Dan Wang, He Li, Ke Kong, Kunkun Xu, Prof. Binyuan Liu, Prof. Ruihu Wang
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202514750. Read article.

From a modular synthesis of nonphosphine chiral nitrogen-based chiral imidazoline-amino acid ligands, two new chiral imidazoline-proline-copper catalysts are developed for targeting exo-selective [3 + 2] cycloaddition reaction. Density functional theory studies rationalize the observed stereoselectivity and the distinct chiral pockets of the two catalysts account for their different substrate compatibility.

[Research Article]
Yan Yu, Takuya Shimada, Chihiro Tokumitsu, Ayaka Fujiwara, Takayoshi Arai
ChemistryEurope, https://doi.org/10.1002/ceur.202500260. Read article.

C3-Symmetric aluminum chelate complexes endowed with tripodal tris-silanolate ligands are shown to be excellent catalysts for the selective carbonyl ene-type cyclization of citronellal to isopulegol as the key intermediate of the current industrial syntheses of menthol. Their chemical and thermal stability make product isolation by distillation possible and enable multiple reuse of the active species.

[Research Article]
J. Nepomuk Korber, Alois Fürstner
ChemistryEurope, https://doi.org/10.1002/ceur.202500251. Read article.

This work provides fundamental chemical insights from the intracellular vesicle perspective into how exercise improves vesicle secretory function, suggests that exercise enhances neurotransmitter storage and release by upregulating exocytosis-associated proteins (i.e., F-actin, myosin II, VAMP, SNAP-25, and Munc-18) and increasing calcium influx.

[Research Article]
Ran Liu, Prof. Xiulan He, Dr. Jing Liu, Dr. Zhining Sun, Prof. Ping Yu, Prof. Lijuan Hou, Prof. Lanqun Mao
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202511277. Read article.

The first catalytic asymmetric IEDDA/cheletropic retro-[4+1] cycloadditions, using thiophene S,S-dioxides (TDOs) and 3-substituted indoles as reaction partners, are realized by a chiral Fe(III)/BOX complex. A series of cyclohexa-fused tricyclic indolines bearing a bridgehead quaternary stereogenic center are synthesized in good yields and excellent enantioselectivities. The synthetic value of this method is demonstrated by the concise total synthesis of pentacyclic Strychnos indole alkaloid (+)-geissoschizoline.

[Research Article]
Shi-Xiong Feng, Qi-Tao Lu, Yang Lu, Lixin Cui, Prof. Dr. Limin Yang, Akanksha Singh Baghel, Prof. Dr. Quan Cai
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202512345. Read article.

Heterometallic complexes showcasing Co-Zn interactions have been synthesized through straightforward salt metathesis methods. Their reaction with white phosphorus yields a dimeric sandwich complex containing bridging P2 units. A stepwise mechanism for its formation is proposed, supported by the isolation of intermediates. Chemical oxidation results in a phosphorus-rich tripeldecker complex which contains a cyclo-P4 middledeck.

[Research Article]
Marco D. Fritz, John A. Kelly, Gábor Balázs, Robert Wolf
ChemistryEurope, https://doi.org/10.1002/ceur.202500257. Read article.

Antioxidant, anti-inflammatory, cardioprotective, anti-apoptotic, immunomodulatory, neuroprotective, mitoprotective, antimicrobial and anticancer properties comprise the multitarget biological activity demonstrated so far investigating lemon, grapefruit, orange, red orange and mandarin IntegroPectin in both in vitro and in vivo studies. A critical perspective towards production and practical uptake of this new class of bioproducts for the treatment and prevention of numerous ailments concludes this account.

[Review]
Dr. Rosaria Ciriminna, Prof. Valentina Di Liberto, Dr. Lorenzo Albanese, Dr. Giovanna Li Petri, Dr. Chiara Valenza, Dr. Giuseppe Angellotti, Dr. Francesco Meneguzzo, Dr. Mario Pagliaro
ChemFoodChem, https://doi.org/10.1002/cfch.202500014. Read article.

Propylene-ethylene copolymer covalent adaptable networks (PEC CANs) are synthesized via one-step, radical-based reactive processing with the use of initiator, dynamic cross-linkers, and vinyl aromatic additives. The best CAN suppresses over 98% of creep at 100 °C (semicrystalline state) for 10,000 s compared to neat PEC. The same CAN is reprocessable either through compression molding or twin-screw extrusion.

[Research Article]
Yen-Wen Huang, Mathew J. Suazo, Stephanie M. Barbon, Hayley A. Brown, Evelyn Auyeung, Colin Li Pi Shan, John M. Torkelson
ChemSusChem, https://doi.org/10.1002/cssc.202501137. Read article.

The working mechanism of a specific pH-responsive luminescence probe, Ratio-pHCL-1, is studied using density functional theory and Marcus theory. The study reveals a three-stage mechanism involving pH-driven structural changes, gradually reversible charge-transfer initiated luminescence, and intramolecular energy transfer. The findings explain the origin of ratiometric chemiluminescence and offer insights for designing new types of pH-responsive luminescence probes.

[Research Article]
Shuangqi Pi, Ya-Jun Liu
ChemPhysChem, https://doi.org/10.1002/cphc.202500437. Read article.

In this Highlight, recent reports are presented featuring three unique catalysts—Ir-based, TXT, and Al-Salen—demonstrating how the EnT process can generate triplet diradicals to form attractive cyclic architectures via intramolecular cyclization. Extensive experimental and theoretical studies have provided valuable insights, informing future strategies and potential implementations.

[Highlight]
Nirbhik Chatterjee
Asian Journal of Organic Chemistry, https://doi.org/10.1002/ajoc.70170. Read article.

Nitric oxide induces decomposition of electron-deficient aminoferrocene drugs 4 with formation of oxime 7, which is derived from the upper cyclopentadienyl ligand. Drugs 4 are not responsive to hydrogen peroxide. Based on the latter reaction, the fluorogenic probes are developed for detecting NO in cells and inflammation in vivo.

[Research Article]
Roman Selin, Hülya Gizem Özkan, Galyna Bila, Rostyslav Bilyy, Andriy Mokhir
ChemMedChem, https://doi.org/10.1002/cmdc.202500356. Read article.

This manuscript presents a series of eight small compounds based on the α-cyanostilbene motif and with different substituents. Three of these compounds show good rates of chloride transport, as well as selectivity for chloride over hydroxide, bicarbonate, and fluoride anions.

[Research Article]
Dr. Anurag Singh, Dr. Lau Halgreen, Priyanka Rani Panda, Dr. Aaron Torres-Huerta, Dr. Nikolay Tumanov, Prof. Johan Wouters, Dr. Hennie Valkenier
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502050. Read article.

Operando substrate curvature measurements are used to monitor the mechanical stress of hard carbon composite electrodes during sodiation and desodiation. The observed asymmetry of the electrode volume between sodiation and desodiation is explained by an interaction between sodium intercalation and pore filling: during pore filling, the sodium concentration in the transport paths is higher than during pore depletion.

[Research Article]
Stefan Mück, Dominik Kramer, Krishnaveni Palanisamy, Christine Kranz, Reiner Mönig
ChemSusChem, https://doi.org/10.1002/cssc.202501272. Read article.

The influence of the length of the aromatic walls of methylene-bridged glycoluril-dimer-derived molecular clips on their binding affinity toward a panel of planar aromatic cations is reported. We find that anthracene-walled host H2 generally binds ≈ 10-fold stronger to a specific guest than naphthalene-walled H1.

[Research Article]
Collin J. Vincent, Dr. David King, Dr. Steven L. Murkli, Prof. Dr. Lyle Isaacs
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502177. Read article.

Idealized models such as the Wulff construction provide inaccurate structures for small supported nanoparticles (NPs). Global optimization via machine learning interatomic potentials (MLIPs) enables finding reshaped, more realistic, and more stable structures in quantitative agreement with microcalorimetric measurements.

[Research Article]
Tristan Maxson, Prof. Dr. Tibor Szilvási
Angewandte Chemie Novit 2025, 1, 0. Read article.

A plasmonic Au@Au3Pd catalyst that integrates visible-light-driven hot electron generation with bimetallic electronic tuning to steer the selective hydrogenation of cinnamaldehyde toward propylbenzene is reported. Localized surface plasmon resonance excitation modulates reaction pathways on tailored Au-Pd interfaces, enabling product selectivity under mild conditions.

[Research Article]
Sana Frindy, Shiqi Wang, Sam Sullivan-Allsop, Rongsheng Cai, Thomas J. A. Slater, Sarah J. Haigh, Pedro H. C. Camargo
ChemSusChem, https://doi.org/10.1002/cssc.202501054. Read article.

Non-noble metal complexes are employed as co-catalysts of m-TiO2 to improve the photocatalytic production of green hydrogen from water photolysis. Six new copper(I) pyridinium-selenolate complexes have been fully characterized and utilized for the development of photocatalysts intended for heterogeneous photocatalysis.

[Research Article]
Leonardo Carneiro Lanes, Rodrigo Cervo, Robert Alan Burrow, Bernardo Almeida Iglesias, Natália de Freitas Daudt, Ernesto Schulz Lang, Bárbara Tirloni, Roberta Cargnelutti
European Journal of Inorganic Chemistry, https://doi.org/10.1002/ejic.202500295. Read article.

HgCl2(C3N6H6), a layered hybrid material, is obtained by combining mercury(II) chloride and melamine in a hydrothermal synthesis. It crystallizes in a non-centrosymmetric structure and exhibits strong second-harmonic generation. The thermally stable compound features a distorted octahedral coordination environment of mercury ions. Structural, spectroscopic, and density functional theory analyses highlight its potential as a nonlinear optical material.

[Research Article]
Melena Groß, Patrick Schmidt, Carl P. Romao, David Enseling, Thomas Jüstel, Mykhailo Brytskyi, Scott Kroeker, Hans-Jürgen Meyer
European Journal of Inorganic Chemistry 2025, 0. Read article.