Chirality Sensors for NMR Spectroscopy

  • Author: Xin Su
  • Published: 11 March 2015
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of the American Chemical Society/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Chirality Sensors for NMR Spectroscopy

Chiral chromatography is one of the most common techniques to discriminate between enantiomers, as well as determine enantiomeric excess of chiral samples. However, certain classes of compounds, such as aliphatic amines, are challenging to separate using chromatographic methods.

Yanchuan Zhao and Timothy M. Swager, Massachusetts Institute of Technology (MIT), Cambridge, USA, have designed a chemosensory platform based on a fluorine-containing chiral Pd pincer scaffold. Upon binding to different chiral amines, the 19F NMR signals of the ligand's fluorine atoms exhibit distinct shifts, forming the basis for qualitative characterization. Owing to its high sensitivity, this platform can identify up to 12 chiral amines at the same time. More importantly, the novel design approach could lead to sensors targeting other important chiral compounds.


Article Views: 3261

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH