Silvery Sheen for Fluorination

Silvery Sheen for Fluorination

Author: David Bradley

Fluorinated aromatics are used in drugs, agrochemicals, and in positron emission tomography tracers. Unfortunately, making carbon-fluorine bonds is hard and uses expensive palladium catalysts; for complex molecules it is harder still.

Now, Tobias Ritter and co-workers, Harvard University, USA, have remedied this situation and made it possible to fluorinate aryl groups, even in crowded molecules, using less-expensive silver to catalyze a cross-coupling reaction. Specifically, the team has proved the viability of the approach using silver oxide to catalyze the fluorination of aryl tin compounds with an electrophilic fluorine compound.

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