New Receptor Controls Blood Pressure

  • Author: Veronika Belusa (image ©: MPI for Heart and Lung Research)
  • Published: 29 July 2015
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of Clinical Investigation/American Society for Clinical Investigation
thumbnail image: New Receptor Controls Blood Pressure

Controlling blood pressure is one of the body's most complex control functions. High blood pressure (hypertension) is a primary risk factor in the development of many cardiovascular diseases. The underlying molecular mechanisms, however, are still not fully understood.

Stefan Offermanns, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany, and colleagues found that the P2Y2 receptor, a docking site for ATP, is located in the middle of the regulatory mechanism. Switching off this receptor in mice, lead to an increase of their blood pressure. In blood vessel cells, the P2Y2 receptor is activated indirectly via the shear stresses of the flowing blood. At the end of a reaction cascade, whose components the team also identified, nitrogen monoxide is formed. It relaxes the blood vessel wall and by this reduces blood pressure.

The scientists want to examine the extent to which malfunctions in this key blood pressure regulation principle are responsible for the development of vascular diseases such as hypertension and atherosclerosis.

Microscopic image of a cross-section of a blood vessel shows the thin inner layer of cells (endothelium; green)
and the vascular muscle cells (red). Cell nuclei (blue). © MPI f. Heart and Lung Research


 

Article Views: 1983

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission and consult our permisson guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH