Biopolymer Sponges Enhance Drug Absorption

  • Author: Jenna Pope
  • Published: 20 October 2015
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of Applied Polymer Science/John Wiley & Sons
thumbnail image: Biopolymer Sponges Enhance Drug Absorption

Self-microemulsifying drug delivery systems can improve the oral bioavailability of certain lipophilic drugs. Ruedeekorn Wiwattanapatapee, Prince of Songkla University, Songkhla, Thailand, and colleagues studied systems made from biopolymer sponges, which have many desirable properties as drug carriers. They are non-irritating, non-mutagenic, non-allergenic, non-toxic, and naturally degradable in the body.

The sponges were formed by freeze drying aqueous gels of the biopolymer along with the active drug. Freeze drying forms a porous polymeric network that traps the bioactive compound. A variety of sponges were formed from hydroxypropylmethyl cellulose samples ranging in viscosity, methoxyl percentage, and hydroxypropyl amount. Along with using fewer ingredients than traditional gel capsules, the method has the added benefit of avoiding organic solvent residue.

Curcumin was used as the active drug because it is practically insoluble in water and has anti-oxidative and anti-inflammatory properties. The researchers first studied the in vitro release of curcumin. All types of sponge showed immediate release of curcumin, with nearly complete release within 120 minutes. The researchers also carried out in vivo studies in rabbits. The sponges significantly enhanced oral absorption compared with an aqueous suspension of curcumin, which is especially interesting as the sponges contained only a quarter of the amount of curcumin in the suspension.


Article Views: 2687

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

CONNECT: on Facebook on Twitter on YouTube on LinkedIn Sign up for our free newsletter

Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH