How Vaccines Change The Immune Response

  • Author: Carmen Tchen
  • Published: 23 October 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: European Journal of Immunology/Wiley-Blackwell
thumbnail image: How Vaccines Change The Immune Response

Leishmaniasis caused by Leishmania major is a neglected, emerging disease that produces open sores, scarring and disfigurement. As a paradigmatic skin infection, it is an excellent model for the study of dermal immunity.

Susana Mendez and colleagues, Baker Institute for Animal Health, Cornell University, USA, previously reported that vaccination of mice with live L. major plus the adjuvant CpG DNA prevents disease and provides long-term immunity.
Here, Wenhui Wu, Lu Huang, and Susana Mendez further characterize the components of adaptive immunity that are unique to this successful live vaccine.
The authors demonstrate that vaccination of mice with live L. major plus CpG DNA causes the specific induction of Th17 cells, which enhances the development of a protective cellular immunity against the parasite. This contrasts with the highly polarized Th1 response caused by L. major alone.

Their findings suggest that vaccines combining live pathogens with immunomodulatory molecules may strikingly modify immunity to infection in a different manner to killed or subunit vaccines.

Article Views: 3621

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH