Drug Delivery with Nanoshuttles

  • Author: ChemistryViews
  • Published: 08 November 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Small/Wiley-VCH
thumbnail image: Drug Delivery with Nanoshuttles

Nanoshuttles, precisely guided and controlled by a doctor, have the potential to transport therapeutic agents directly to diseased tissues. This improves the therapeutic efficacy and reduces systemic side effects of highly toxic drugs.


Joseph Wang and co-workers, University of California, San Diego, USA, report the proof-of-concept of drug carrier transport and delivery by a catalytic nanoshuttle. The nanoshuttles picked-up drug-loaded poly-D,L-lactic-co-glycolic acid (PLGA) particles and transported them over predefined routes to target destinations.


The loading and release of the drug-loaded particles was controlled by the magnetic attraction between a nickel segment of the nanoshuttle and iron oxide nanoparticles contained with the PLGA particles. The loading and release are instantaneous and the PLGA particles were delivered three orders of magnitude faster than particles transported by Brownian motion.


Article Views: 3813

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)published by Wiley-VCH