Laser-Directed Cancer Chemotherapy

  • Author: Adrian Neal
  • Published: 28 March 2016
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of Medicinal Chemistry/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Laser-Directed Cancer Chemotherapy

Photodynamic therapy (PDT) is a cancer treatment that uses tissue-penetrating light to activate a photosensitizer. The resulting generation of toxic reactive oxygen species, in particular singlet oxygen, can be localized to the tumor. Problems with this approach occur when cancer cells escape the reach of singlet oxygen, which has a short half-life and a limited diffusion distance in tissue. If they do, the cancer can come back.


Youngjae You and colleagues, University of Oklahoma, Oklahoma City, USA, have coupled a sensitizer (a phthalocyanine) with paclitaxel, a cancer drug routinely used to treat many types of the disease. Their conjugate is designed to produce singlet oxygen upon illumination, which causes damage to the cancer cells and also cleaves the aminoacrylate linker between drug and photosensitizer. This releases paclitaxel into the surroundings of the tumor at which the light is aimed.


This prodrug mechanism of action was confirmed in experiments that showed that the phthalocyanine-paclitaxel conjugate is much less cytotoxic than the parent drug until activation with 690 nm light, which led to the death of ovarian cancer cells. These results could aid prodrug design, not only for paclitaxel, but also for a broad panel of other drugs for which a more directed delivery might be beneficial.


 

Article Views: 2196

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH