Graphene Hydrogel Membranes Guide Bone Regeneration

  • Author: ChemistryViews.org
  • Published: 05 April 2016
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Advanced Materials/Wiley-VCH
thumbnail image: Graphene Hydrogel Membranes Guide Bone Regeneration

Graphene-based materials could be useful for medical applications due to their good mechanical properties, their versatile morphology, and the possibility of chemical functionalization. However, there have been few examples of graphene materials specifically targeted and tested for such applications.


Derong Zou, Shanghai Jiao Tong University, China, Dan Li, Monash University, Australia, and colleagues have developed and tested a multilayered graphene hydrogel (MGH) membrane as a barrier membrane for guided bone regeneration (pictured). The membrane consists of multiple stacked chemically converted graphene (CCG) sheets. This roughly mimics the collagen fibers which combine with the inorganic hydroxyapatite in bones.


The team synthesized CCG by chemical reduction of a graphene oxide solution and filtered the resulting dispersion, which left the MGH membranes on the filter. The resulting material is strong, yet flexible, and nanochannels allow for the quick diffusion of nutrients. The researchers tested the membranes' potential in guided bone regeneration, using skull defects in rats as a model. They compared the new material to titanium, which is commonly used to cover such bone defects.


The membranes successfully maintained osseous space, promoted early bone growth, and sped up mineralization compared to titanium. They adhered well to neighboring bone tissue and remained in place for eight weeks. The MGH membranes' nanostructure resulted in improved osteoblast adhesion and apatite deposition. These results suggest that graphene-based membranes are promising candidates material for guided bone regeneration.


 

Article Views: 12570

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH