Two regioisomeric benzotriazole-based covalent organic frameworks (COFs) are successfully constructed for the first time. The N-2-methyl substituted COF shows a superior photocatalytic efficiency with a hydrogen evolution rate up to 17,900 μmol g−1 h−1, far outperforming that of its isomer (1360 μmol g−1 h−1) under the same conditions.

[Research Article]
Shuzhi Yao, Guanyu Shi, Shi Feng, Qingchuan Zheng, Zhiguang Song, Xiaoming Liu
ChemSusChem, https://doi.org/10.1002/cssc.202501657. Read article.

Photoconversion of phytochrome causes structural alterations in the chromophore binding pocket, associated with local electric field changes, which are analyzed by experimental and theoretical methods. The field changes propagate to the distant tongue region of the protein. Magnitude of the field changes may be an important factor contributing to the functionally essential secondary structure transition of the tongue.

[Research Article]
Mariafrancesca La Greca, Anh Duc Nguyen, Anastasia Kraskov, Norbert Michael, Luisa Sauthof, Manal Ebrahim, Sagie Katz, Johannes von Sass, Oan Tu Hoang, Nediljko Budisa, Patrick Scheerer, Ramona Schlesinger, Maria Andrea Mroginski, Peter Hildebrandt
ChemPhysChem, https://doi.org/10.1002/cphc.202500595. Read article.

Amyloid-selective catalytic photooxygenation reduces amyloid toxicity, aggregation tendencies, and seeding activities. Achieving therapeutic catalysis for intracellular amyloids is challenging due to conflicting oxygenation and reductive cellular environments. We present the first catalytic photooxygenation of α-synuclein amyloids in living cells by developing a catalyst that features an amyloid-sensing molecular switch with an ene-yne structure.

[Research Article]
Atsushi Iwai, Youhi Hwang, Hiroki Umeda, Taka Sawazaki, Ikumi Tomizawa, Maiko Ono, Makoto Higuchi, Youhei Sohma, Yukiko Hori, Taisuke Tomita, Harunobu Mitsunuma, Motomu Kanai
ChemistryEurope, https://doi.org/10.1002/ceur.202500192. Read article.

Chloride-binding foldamers have been developed that have stereogenic C- and N-terminal groups separated by a helical α-aminoisobutyric acid (Aib) body. Chloride affinity is sensitive to the sense and strength of screw-sense induction by each N-terminal residue. This conformational preference is relayed along the 1-nanometer-long helical foldamer to a bis(squaramide) at the C terminus.

[Research Article]
Rhodri Ll. Evans, Luis Martínez-Crespo, Benedicte Doerner, Rosa M. Gomila, George F. S. Whitehead, Antonio Frontera, Simon J. Webb
ChemistryEurope, https://doi.org/10.1002/ceur.202500195. Read article.

A highly flexible iterative exponential growth strategy is used in combination with the sulfur-phenolate exchange reaction to develop sequence-defined oligosulfonimidates (16 mer). Combining this with sulfur-fluorine exchange-based iterative step growth, a bespoke 20 mer (Mw = 8.5 kDa) can be synthesized.

[Research Article]
Yu Han, Dong-Dong Liang, Silke Heskamp, Bo Chen, Fedor M. Miloserdov, Han Zuilhof
ChemistryEurope, https://doi.org/10.1002/ceur.202500324. Read article.

Alumanyl silyl-substituted coinage metal complexes are synthesized and structurally characterized employing nuclear magnetic resonance and x-ray diffraction measurements. The substituent effect of the silyl group on the respective coinage metal centers is investigated by regioselective CO2 capturing.

[Research Article]
Johannes Voigtland, Moritz Ludwig, Sebastian Stigler, Shigeyoshi Inoue
ChemistryEurope, https://doi.org/10.1002/ceur.202500216. Read article.

Rapaprotin is a novel inhibitor of the 26S proteasome. The cyclic rapaprotin is a pro-drug. Upon entry into cancer cells, it undergoes cleavage by prolyl endopeptidase to give rise to the active linear rapaprotin-L, which induces the disassembly of the 26S proteasome and impairs its function. This unprecedented mechanism of action is attributable to the selectivity of rapaprotin for cancer cells and its synergy with existing proteasome inhibitory drugs.

[Research Article]
Hanjing Peng, Zufeng Guo, Wei Li Wang, Deyao Yin, Shitao Zou, Thomas Asbell, Brett R. Ullman, Maya Thakar, Feiran Zhang, Sam Y. Hong, A. V. Subba Rao, Kunyu Wang, Shuwen Zhang, Zhaolong Wu, Xuemei Li, Aidan A. Kendra, Seth S. Margolis, William H. Matsui, Christian B. Gocke, Youdong Mao, Jun O. Liu
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202500288. Read article.

A dual-regulation strategy was proposed to simultaneously modulate the reduction center via heteroatom substitution and the oxidation center via TEMPO coordination in Co-porphyrin MOFs (Co-N4-MOFs) to afford a strong redox photocatalyst TEMPO@Co-SN3-PCN. Remarkably, the system with TEMPO@Co-SN3-PCN achieves a CO yield of 2000 µmol g−1, over 50 times higher than that with the conventional Co-N4-PCN.

[Research Article]
Zhe Wu, Dr. Yu-Rong Guo, Xiao-Liang Ma, Prof. Zhi-Ming Zhang, Prof. Tong-Bu Lu, Dr. Song Guo
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202514515. Read article.

A novel rigid tetradentate Pt(II) emitter (PtCK1) was developed via strategic molecular engineering. Top-emitting PhOLED based on PtCK1 achieved a record-high peak blue index (BI) of 397 cd A−1 CIEy−1 with CIEy < 0.05, meeting the BT.2020 blue color gamut standard.

[Research Article]
Dr. Kewei Xu, Chengyao Zhang, Liping Yang, Dr. Feng Zhan, Weiwei Lou, Prof. Yun-Fang Yang, Prof. Yuanbin She, Prof. Guijie Li
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202517695. Read article.

A wet-chemistry synthetic protocol is developed for the creation of rare earth (RE) confined high-entropy alloy (HEA-RE) nanocrystals (NCs) with rich surface cavities and lattice distortions via a general high-entropy (HE)-induced confinement strategy, featuring atomically dispersed RE confined in HE Pt-based frameworks. These HEA-RE NCs serve as multi-synergistic catalysts for nitrate-to-ammonia reduction, demonstrating the multiple proton- and electron-coupled complex reactions.

[Research Article]
Yong Jiang, Hao Fu, Ziyun Zhong, Yingnan Duan, Mengdie Jin, Wenshuo Zhang, Dr. Zhichao Zeng, Dr. Chao Gu, Prof. Yaping Du
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202515842. Read article.

A comprehensive investigation of laser-induced covalent patterning, defunctionalization, and refunctionalization of single-layer graphene with aryl diazonium salts is reported. Scanning Raman microscopy verifies spatial control, while systematic variation of laser parameters and substituent effects highlights the versatility of the method. The demonstrated “write-erase-rewrite” capability establishes a robust platform for micrometer-scale fabrication of complex, functionalized graphene architectures.

[Research Article]
Johanna Krüger, Tamara Nagel, Bowen Yang, Dr. Frank Hauke, Prof. Andreas Hirsch
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502468. Read article.

Powdered elemental bismuth in water forms 2D bismuth oxycarbonate nanosheets under high shear in a rapidly rotating tube housed in a vortex fluidic device, without the need of surfactants or other excipients, with uptake of atmospheric carbon dioxide.

[Research Article]
Fayed Abdullah Alrashaidi, Jason R. Gascooke, Mohammed Z. Asiri, Abigail K. Mann, Ashley Slattery, Jonathan A. Campbell, Youhong Tang, Colin L. Raston
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502202. Read article.

An integrative data-driven approach leveraging AI, computations, and robotic experimentation enables accelerated discovery of polyoxometalates, bridging synthetic unpredictability and paving the way for rational, predictive, and functional cluster chemistry.

[Perspective]
Aleksandar Kondinski, Nadiia I. Gumerova, Annette Rompel, Paolo Falcaro, Tobias Schreck
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202501528. Read article.

Antioxidant, anti-inflammatory, cardioprotective, anti-apoptotic, immunomodulatory, neuroprotective, mitoprotective, antimicrobial and anticancer properties comprise the multitarget biological activity demonstrated so far investigating lemon, grapefruit, orange, red orange and mandarin IntegroPectin in both in vitro and in vivo studies. A critical perspective towards production and practical uptake of this new class of bioproducts for the treatment and prevention of numerous ailments concludes this account.

[Review]
Dr. Rosaria Ciriminna, Prof. Valentina Di Liberto, Dr. Lorenzo Albanese, Dr. Giovanna Li Petri, Dr. Chiara Valenza, Dr. Giuseppe Angellotti, Dr. Francesco Meneguzzo, Dr. Mario Pagliaro
ChemFoodChem 2025, 1, 0. Read article.

Propylene-ethylene copolymer covalent adaptable networks (PEC CANs) are synthesized via one-step, radical-based reactive processing with the use of initiator, dynamic cross-linkers, and vinyl aromatic additives. The best CAN suppresses over 98% of creep at 100 °C (semicrystalline state) for 10,000 s compared to neat PEC. The same CAN is reprocessable either through compression molding or twin-screw extrusion.

[Research Article]
Yen-Wen Huang, Mathew J. Suazo, Stephanie M. Barbon, Hayley A. Brown, Evelyn Auyeung, Colin Li Pi Shan, John M. Torkelson
ChemSusChem, https://doi.org/10.1002/cssc.202501137. Read article.

The working mechanism of a specific pH-responsive luminescence probe, Ratio-pHCL-1, is studied using density functional theory and Marcus theory. The study reveals a three-stage mechanism involving pH-driven structural changes, gradually reversible charge-transfer initiated luminescence, and intramolecular energy transfer. The findings explain the origin of ratiometric chemiluminescence and offer insights for designing new types of pH-responsive luminescence probes.

[Research Article]
Shuangqi Pi, Ya-Jun Liu
ChemPhysChem, https://doi.org/10.1002/cphc.202500437. Read article.

In this Highlight, recent reports are presented featuring three unique catalysts—Ir-based, TXT, and Al-Salen—demonstrating how the EnT process can generate triplet diradicals to form attractive cyclic architectures via intramolecular cyclization. Extensive experimental and theoretical studies have provided valuable insights, informing future strategies and potential implementations.

[Highlight]
Nirbhik Chatterjee
Asian Journal of Organic Chemistry, https://doi.org/10.1002/ajoc.70170. Read article.

Nitric oxide induces decomposition of electron-deficient aminoferrocene drugs 4 with formation of oxime 7, which is derived from the upper cyclopentadienyl ligand. Drugs 4 are not responsive to hydrogen peroxide. Based on the latter reaction, the fluorogenic probes are developed for detecting NO in cells and inflammation in vivo.

[Research Article]
Roman Selin, Hülya Gizem Özkan, Galyna Bila, Rostyslav Bilyy, Andriy Mokhir
ChemMedChem, https://doi.org/10.1002/cmdc.202500356. Read article.

Operando substrate curvature measurements are used to monitor the mechanical stress of hard carbon composite electrodes during sodiation and desodiation. The observed asymmetry of the electrode volume between sodiation and desodiation is explained by an interaction between sodium intercalation and pore filling: during pore filling, the sodium concentration in the transport paths is higher than during pore depletion.

[Research Article]
Stefan Mück, Dominik Kramer, Krishnaveni Palanisamy, Christine Kranz, Reiner Mönig
ChemSusChem, https://doi.org/10.1002/cssc.202501272. Read article.

This manuscript presents a series of eight small compounds based on the α-cyanostilbene motif and with different substituents. Three of these compounds show good rates of chloride transport, as well as selectivity for chloride over hydroxide, bicarbonate, and fluoride anions.

[Research Article]
Dr. Anurag Singh, Dr. Lau Halgreen, Priyanka Rani Panda, Dr. Aaron Torres-Huerta, Dr. Nikolay Tumanov, Prof. Johan Wouters, Dr. Hennie Valkenier
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502050. Read article.