Systematic control over coordination environments and subcomponent sequences enabled the formation and stabilization of trefoil perplexanes and trefoil tetrahedral knotted cages. Peripheral crosslinkers diminished framework stability to tune host-guest behavior and dynamic exchange, while mechanical entanglement modulated self-sorting and guest binding, offering routes to future functional designs.

[Research Article]
Dr. Yuchong Yang, Sabrina Y. Hu, Dr. Tanya K. Ronson, Paula C.P. Teeuwen, Dr. Sudhakar Gaikwad, Dr. Andrew W. Heard, Prof. David J. Wales, Prof. Jonathan R. Nitschke
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202519491. Read article.

Cucurbit[6]uril-anchored copper (CB[6]-Cu) is reported as a stable single-site catalyst, achieving a 95.39% Faradaic efficiency for C2H4 at 300 mA cm−2 in electrocatalytic acetylene hydrogenation (EAH). The single-Cu-site and adjacent cavity structure facilitates optimal reactant coverage and disrupted hydrogen bonding, suppressing side reactions. The general applicability of this strategy is shown with CB[6]-Co for hydroxylamine synthesis.

[Research Article]
Yichen He, Fanpeng Chen, Dr. Bo-Hang Zhao, Dr. Chuanqi Cheng, Prof. Bin Zhang
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202518663. Read article.

Modular design of PTzBI-dF-Si balances solubility and aggregation in o-xylene, enabling fibrillar morphologies and mechanically robust stretchable organic solar cells.

[Research Article]
Xuanang Luo, Xinrui Liu, Youran Lin, Mingke Li, Zhiyuan Yang, Zhihui Xiong, Yang Wang, Dr. Feng Peng, Prof. Wenkai Zhong, Prof. Ning Li, Prof. Lei Ying
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202514985. Read article.

This work demonstrates synergistic lanthanide salt recovery from an aqueous magnet leachate to single ppm concentrations using Na2SO4 combined with dimethyl ether crystallization. This waste valorization process minimizes chemicals consumed and waste generated while maximizing the recovery of a critical material product.

[Research Article]
Chloe Tolbert, Caleb Stetson, Denis Prodius, Christopher Orme, David Appy, Ikenna Nlebedim, Aaron D. Wilson
ChemSusChem, https://doi.org/10.1002/cssc.202501383. Read article.

While polymorphs I contain C2-symmetric enantiomers with pronounced azine twists and disrotatory phenyl twists, the acetophenone azine molecules in the new polymorphs II are Ci-symmetric with trans azine moieties and conrotatory phenyl twists. The three polymorphs II exemplify the new Paradigm IV for the supramolecular architectures of “laterally offset diarenes” and result in “shiplap/flat” idioteloamphiphile monolayers (IAMs).

[Research Article]
Harmeet Bhoday, Kaidi Yang, Steven P. Kelley, Rainer E. Glaser
European Journal of Organic Chemistry, https://doi.org/10.1002/ejoc.202500713. Read article.

The prebiotic reaction toward the Wöhler-RNA, a Proto-RNA-candidate, using aldehydes and biuret or triuret results in a mixture of the α- and β- furanosides and pyranosides. Investigation of the interconversion of these isomers shows different reactivity and stability of the biuret and triuret analogues as well as between the corresponding furanosides and pyranosides.

[Research Article]
Nathalie J. Kurrle, Dr. Maximilian Bechtel, Nathalie Hampel, Prof. Dr. Oliver Trapp
ChemSystemsChem, https://doi.org/10.1002/syst.202500046. Read article.

Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed-shell and open-shell systems, expanding reactivity and enabling innovative design strategies.

[Review]
Jaspreet Kaur, Joshua P. Barham
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502075. Read article.

A redox-active Cu(I)-photocatalyst is evaluated for the aziridination of alkenes. Especially styrenes and electron-rich 1,3-dienes are found to be suitable substrates, allowing short reaction times (10 min) at low catalyst loading (1 mol%). The activation of the copper(I) complex by light is compared to the process in the dark.

[Research Article]
Onnicha Khaikate, Kathrin Strunk, Chiara Cabrele, Nattawut Hassa, Chutima Kuhakarn, Oliver Reiser
ChemistryEurope, https://doi.org/10.1002/ceur.202500218. Read article.

Tracking the propagation of periodic concentration perturbations within chemical reactions is presented as a powerful strategy for probing reaction connectivity and the kinetics of individual reaction steps. This approach is demonstrated here for the organocatalytic Michael-type addition of cyclopentadiene to α,β-unsaturated aldehydes, based on relative phase delays in ion intensities measured by electrospray ionization-mass spectrometry.

[Research Article]
Charlotte Lefebvre, Quentin Duez
ChemistryEurope, https://doi.org/10.1002/ceur.202500266. Read article.

Analyze the storage mechanism of hard carbon materials in alkali metal ion batteries, explore the relationship between microstructure and performance, and provide countermeasures to improve performance.

[Review]
Ping Lin, Laibing Wang, Xiuli Wang, Yu Zhong, Jiangping Tu
ChemistryEurope, https://doi.org/10.1002/ceur.202500123. Read article.

Oxygen evolution reaction (OER), hindered by sluggish kinetics and intricate catalytic mechanisms, remains a key bottleneck in water splitting. In this work, selectively doping single-atomic Ir into NiMoO4 enables a synergistic adsorbate evolution mechanism and lattice oxygen mechanism (AEM-LOM), achieving superior performance: low overpotential (253 mV at 10 mA cm−2), remarkable stability (>1000 h), and practical applicability in water electrolyzers.

[Research Article]
Jinli Zhu, Xuebing Peng, Mi Guo, Yuhang Liu, Prof. Dongliang Chao, Prof. Daqiang Gao, Prof. Laiquan Li
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202516903. Read article.

Mono- and biphasic semihydrogenation of alkynes is catalyzed by water-dispersed palladium nanoparticles of various size, shape, and surface coatings at 1 and 50 bar hydrogen pressure. Spherical nanoparticles of 5 nm diameter were most efficient. Ultrasmall nanoparticles (2 nm) showed an increase in metallic character due to reduction by hydrogen during catalysis.

[Research Article]
Niklas Kost, Florian Lehmann, Rui Guo, Kateryna Loza, Marc Heggen, Thomas Seidensticker, Matthias Epple
ChemCatChem, https://doi.org/10.1002/cctc.202501164. Read article.

Two regioisomeric benzotriazole-based covalent organic frameworks (COFs) are successfully constructed for the first time. The N-2-methyl substituted COF shows a superior photocatalytic efficiency with a hydrogen evolution rate up to 17,900 μmol g−1 h−1, far outperforming that of its isomer (1360 μmol g−1 h−1) under the same conditions.

[Research Article]
Shuzhi Yao, Guanyu Shi, Shi Feng, Qingchuan Zheng, Zhiguang Song, Xiaoming Liu
ChemSusChem, https://doi.org/10.1002/cssc.202501657. Read article.

Photoconversion of phytochrome causes structural alterations in the chromophore binding pocket, associated with local electric field changes, which are analyzed by experimental and theoretical methods. The field changes propagate to the distant tongue region of the protein. Magnitude of the field changes may be an important factor contributing to the functionally essential secondary structure transition of the tongue.

[Research Article]
Mariafrancesca La Greca, Anh Duc Nguyen, Anastasia Kraskov, Norbert Michael, Luisa Sauthof, Manal Ebrahim, Sagie Katz, Johannes von Sass, Oan Tu Hoang, Nediljko Budisa, Patrick Scheerer, Ramona Schlesinger, Maria Andrea Mroginski, Peter Hildebrandt
ChemPhysChem, https://doi.org/10.1002/cphc.202500595. Read article.

A highly flexible iterative exponential growth strategy is used in combination with the sulfur-phenolate exchange reaction to develop sequence-defined oligosulfonimidates (16 mer). Combining this with sulfur-fluorine exchange-based iterative step growth, a bespoke 20 mer (Mw = 8.5 kDa) can be synthesized.

[Research Article]
Yu Han, Dong-Dong Liang, Silke Heskamp, Bo Chen, Fedor M. Miloserdov, Han Zuilhof
ChemistryEurope, https://doi.org/10.1002/ceur.202500324. Read article.

A comprehensive investigation of laser-induced covalent patterning, defunctionalization, and refunctionalization of single-layer graphene with aryl diazonium salts is reported. Scanning Raman microscopy verifies spatial control, while systematic variation of laser parameters and substituent effects highlights the versatility of the method. The demonstrated “write-erase-rewrite” capability establishes a robust platform for micrometer-scale fabrication of complex, functionalized graphene architectures.

[Research Article]
Johanna Krüger, Tamara Nagel, Bowen Yang, Dr. Frank Hauke, Prof. Andreas Hirsch
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502468. Read article.

Powdered elemental bismuth in water forms 2D bismuth oxycarbonate nanosheets under high shear in a rapidly rotating tube housed in a vortex fluidic device, without the need of surfactants or other excipients, with uptake of atmospheric carbon dioxide.

[Research Article]
Fayed Abdullah Alrashaidi, Jason R. Gascooke, Mohammed Z. Asiri, Abigail K. Mann, Ashley Slattery, Jonathan A. Campbell, Youhong Tang, Colin L. Raston
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202502202. Read article.

An integrative data-driven approach leveraging AI, computations, and robotic experimentation enables accelerated discovery of polyoxometalates, bridging synthetic unpredictability and paving the way for rational, predictive, and functional cluster chemistry.

[Perspective]
Aleksandar Kondinski, Nadiia I. Gumerova, Annette Rompel, Paolo Falcaro, Tobias Schreck
Chemistry ? A European Journal 2025, 31, 0. Read article.

Antioxidant, anti-inflammatory, cardioprotective, anti-apoptotic, immunomodulatory, neuroprotective, mitoprotective, antimicrobial and anticancer properties comprise the multitarget biological activity demonstrated so far investigating lemon, grapefruit, orange, red orange and mandarin IntegroPectin in both in vitro and in vivo studies. A critical perspective towards production and practical uptake of this new class of bioproducts for the treatment and prevention of numerous ailments concludes this account.

[Review]
Dr. Rosaria Ciriminna, Prof. Valentina Di Liberto, Dr. Lorenzo Albanese, Dr. Giovanna Li Petri, Dr. Chiara Valenza, Dr. Giuseppe Angellotti, Dr. Francesco Meneguzzo, Dr. Mario Pagliaro
ChemFoodChem 2025, 1, 0. Read article.

Propylene-ethylene copolymer covalent adaptable networks (PEC CANs) are synthesized via one-step, radical-based reactive processing with the use of initiator, dynamic cross-linkers, and vinyl aromatic additives. The best CAN suppresses over 98% of creep at 100 °C (semicrystalline state) for 10,000 s compared to neat PEC. The same CAN is reprocessable either through compression molding or twin-screw extrusion.

[Research Article]
Yen-Wen Huang, Mathew J. Suazo, Stephanie M. Barbon, Hayley A. Brown, Evelyn Auyeung, Colin Li Pi Shan, John M. Torkelson
ChemSusChem, https://doi.org/10.1002/cssc.202501137. Read article.