This study reveals that dynamic structural oscillations within the [Ni-O2-Fe] units of NiFe LDHs identified a strong dependence on the alternating active Fe dissolution and redeposition, thus mediating the dynamic stability. Further, engineering the oscillation manners via the in situ sulfur leaching and cobalt-induced electron-withdrawing effects achieves unprecedented industrial-scale durability (>800 h @ 8000 mA) and a record energy efficiency (4.05 kWh Nm−3 H2 at 4000 A m−2).

[Research Article]
Dr. Qunlei Wen, Dr. Tianyang Liu, Dr. Danji Huang, Dr. Yu Lin, Zhenhong Yang, Dr. Ruoou Yang, Prof. Youwen Liu, Prof. Xiaomeng Ai, Prof. Jiakun Fang, Prof. Yafei Li, Prof. Bao Yu Xia, Prof. Shijie Cheng, Prof. Tianyou Zhai
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202509915. Read article.

A systematic matrix approach reveals exponential cathode electrolyte interphase (CEI) growth between 3.7 and 3.9 V versus In/InLi in LiNi0.83Co0.11Mn0.06O2│Li6PS5Cl cells. The matrix enables targeted state-of-charge analysis and highlights a potential hold as a noninvasive CEI formation strategy.

[Research Article]
Melina Witt, Martin A. Lange, Wolfgang G. Zeier
ChemElectroChem, https://doi.org/10.1002/celc.202500237. Read article.

This work reports subtle pH-dependent chirality inversions through designed amphiphilic peptides. The underlying mechanism is revealed to be closely related to the protonation state of the hydrophilic His residue. The protonated His promotes antiparallel β-sheet packing and left-handed fibril assembly, whereas the deprotonated His facilitates parallel packing and right-handed fibril assembly, driven by interstrand His-His interactions.

[Research Article]
Xiaoyue Ma, Kai Qi, Xinfeng Ju, Yawei Sun, Hua Yang, Yubin Ke, Jun Zhang, Yurong Zhao, Hai Xu, Jiqian Wang
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202511407. Read article.

Although organic redox systems are emerging as next-generation energy storage media, stability at high cell voltage is often achieved at the expense of synthetic accessibility. Here, we isolate and characterize a feedstock-derived thiophene radical anion bearing simple ester groups. Despite a minimalist design, the radical and its derivatives are stable at extreme potentials, enabling their use as readily accessible electrolytes for electron storage.

[Communication]
Aurelio C. Gasser, Daniel Käch, Prof. Dr. Máté J. Bezdek
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202512271. Read article.

A photocatalytic, late-stage decarboxylative functionalization of carboxylic acids using gem-borylsilyl alkenes is described. This transformation enables the direct decarboxylative /radical addition of bioactive, naturally occurring, and fatty acids to gem-B,Si alkenes, delivering synthetically valuable alkylboron,silayl under mild, visible-light conditions. A powerful platform for late-stage diversification.

[Research Article]
Nadim Eghbarieh, Ahmad Masarwa
ChemistryEurope, https://doi.org/10.1002/ceur.202500207. Read article.

Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.

[Research Article]
Cedrik Kühling, Wiebke Teich, Bayram Terzi, Helena Schepers, Sabine Hüwel, Andrea Rentmeister
ChemistryEurope, https://doi.org/10.1002/ceur.202500178. Read article.

The benzyl cation is plausibly formed inside zeolites after rearrangement of individually isolated tropylium cations at room temperature. The benzyl cation-entrapped zeolite is stable for weeks without any storage precaution, and a solid-state 13C nuclear magnetic resonance spectrum of this iconic carbocation could be recorded.

[Research Article]
Francesco Orlando, Raúl Pérez-Ruíz, German Sastre, Antonio Leyva−Pérez
ChemistryEurope, https://doi.org/10.1002/ceur.202500217. Read article.

A comparative study of group I tert-amylate precatalysts for hydrophosphination demonstrates increasing reactivity down the group to the first examples of rubidium and cesium in this reaction. Catalytic activity with lighter and more abundant elements, typified by potassium, can be enhanced with a crown ether, demonstrating the importance of ion separation in this nucleophilic catalysis.

[Research Article]
Dr. Diego R. Javier-Jiménez, Dr. Matthew B. Reuter, Emma J. Finfer, Gavin A. Sicard, Prof. Dr. Rory Waterman
ChemCatChem, https://doi.org/10.1002/cctc.202500752. Read article.

A unique class of tubular polymer structures that are soluble in apolar organic solvents but are endowed with polar pores has been created through the rational design of the monomer units, which self-assemble in amphiphilic cyclic entities that then stack into tubular architectures. These tailored assemblies are able to selectively host hydrophilic dye molecules that are complementary in size and chemical affinity for the pore coating, providing containers for the study of energy transfer processes.

[Research Article]
Irene Sancho-Casado, Dr. Fátima Aparicio, Dr. Marina González-Sánchez, Dr. Raquel Chamorro, Dr. Víctor Vega-Mayoral, Dr. Juan Cabanillas-González, Prof. David González-Rodríguez
Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202509156. Read article.

The protein LmrR is a versatile scaffold to design artificial metalloenzymes. Here, we show that the M8D/A92E (DE) mutations that result in a much more efficient catalyst, destabilize the protein dimerization interface and alter the conformation landscape when binding metal cofactor and substrates are shown. These results highlight the intricate relations between protein, metal cofactor, and substrates in defining catalytic efficiency.

[Research Article]
Adil A. Safeer, Fabrizio Casilli, Wouter Beugelink, Gerard Roelfes, Marc Baldus, Hugo van Ingen
ChemBioChem, https://doi.org/10.1002/cbic.202500259. Read article.

Dysprosium in high-symmetry environment: an original crystal-field energetic profile provides an experimental demonstration of the oblate/prolate theory and is also responsible for an unprecedented orange-to-red emission.

[Research Article]
Nimisha Jain, Gregoire David, Marie Cordier, Yan Suffren, Boris Le Guennic, Yann Sarazin, Kevin Bernot
ChemistryEurope, https://doi.org/10.1002/ceur.202500193. Read article.

The built-in electric field in FeCo2O4/ZnCdS heterojunctions regulates the d-band center to optimize hydrogen adsorption energy. An S-scheme charge transfer mechanism achieves a photocatalytic hydrogen evolution rate of 9080 μmol g−1 h−1, surpassing noble-metal cocatalysts. Density functional theory and Kelvin probe force microscope studies confirm that interfacial electric field engineering enhances carrier separation and reaction kinetics, providing an efficient noble-metal-free strategy.

[Research Article]
Shuai Wang, Yihu Ke, Fei Jin, Youji Li, Zhiliang Jin
ChemSusChem, https://doi.org/10.1002/cssc.202500950. Read article.

Ground and excited-state redox potentials of a few axially chalcogenated phosphorus-corroles (XPC; XO, S, Se) are reliably obtained using the range-separated hybrid density functional theory in acetonitrile.

[Research Article]
Annette Mariya Tedy, Arun K. Manna
ChemPlusChem, https://doi.org/10.1002/cplu.202500137. Read article.

DESI is a novel lysine covalent warhead with moderate reactivity and hydrolytic stability, which can form a stable six-membered cyclic adduct with lysine. DESI-derived EGFR allosteric inhibitor 4 selectively modifies the catalytic lysine K745, thus potently inhibiting the activity of EGFRL858R/T790M/C797S kinase and corresponding engineered BaF3 cell proliferation as a single agent.

[Research Article]
Huiqi Xu, Hongjin Zhang, Suyun Jia, Yanxin Tao, Quanpeng Wei, Yingao Wang, Xuechen Liu, Yuqing Zhang, Xinpeng Ning, Yuyan Shi, Dr. Can Jin, Prof. Dr. Ke Ding, Prof. Dr. Dawei Ma, Dr. Shan Li, Dr. Mengyang Fan
Chemistry ? A European Journal 2025, 31, 0. Read article.

Backbone Thz moieties prevail in bioactive peptidic natural products and play important roles in their biological functions. Here, we report an in vitro selection platform for Thz-containing macrocyclic peptides, established through a posttranslational chemoenzymatic transformation. This study establishes a robust system to expedite ligand development in pseudo-natural peptide discovery.

[Research Article]
Akihiro Saito, Dr. Hiroyuki Kimura, Prof. & Dr. Hiroyasu Onaka, Prof. & Dr. Hiroaki Suga, Prof. & Dr. Yuki Goto
Chemistry ? A European Journal, https://doi.org/10.1002/chem.202501355. Read article.

By introducing analogues of Trp in Ar/Trp cell-penetrating peptides, we investigated the role of this unique amino acid in the cell uptake and interaction with cell membrane partners using experimental and computational approaches.

[Research Article]
Dr. Sonia Khemaissa, Dr. Antonio Bauzá, Dr. Émilie Lesur, Françoise Illien, Dr. Sandrine Sagan, Prof. Antonio Frontera, Dr. Astrid Walrant
Chemistry ? A European Journal 2025, 31, 0. Read article.

Herein, a novel multicomponent aza-Prins strategy is presented to synthesize decorated piperidine-fused dihydroquinazolinones. A bifunctional aldehyde is reacted with a homoallylic amine in a one-pot cascade fashion to afford a highly reactive N-acyliminium ion. By the addition of various nucleophiles, 4-substituted piperidines can be obtained with high levels of diastereoselectivity.

[Research Article]
Lovisa Dybeck, Morgane Baudoin, Luke R. Odell
European Journal of Organic Chemistry 2025, 0. Read article.

We describe the Fe-catalyzed double hydroboration of nitriles using HBpin as the terminal reductant. Mechanistic studies, both experimental and computational, reveal a unique and unreported mechanistic pathway for iron-catalyzed hydroboration where reductive elimination, rather than B─H bond activation is the rate- limiting step.

[Research Article]
Laura A. Grose, Yi Zhang, Samuel Oultram, Ryan J. Schwamm, Dr. Sam. P. de Visser, Dr. Darren Willcox
Chemistry ? A European Journal 2025, 31, 0. Read article.

The oxidation of β-chlorohydrins is thermodynamically unfavourable. To solve this, different photocatalytic systems are explored under white light irradiation. Best results are achieved using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in stochiometric or catalytic loadings including tert-butyl nitrite/O2 as regeneration system. Thus, the synthesis of several α-haloketones is accomplished, which are employed as intermediates in multistep chemoenzymatic cascades.

[Research Article]
Sara Filgueira, Laura Rodríguez-Fernández, Iván Lavandera, Vicente Gotor-Fernández
ChemSusChem, https://doi.org/10.1002/cssc.202500683. Read article.

Managing synthetic polymer waste is a major challenge. While enzymatic polyamide (PA) hydrolysis holds great recycling potential, it is limited by ineffective polyamidases. The polyamidase NylCp2-TS is evolved through random mutagenesis and incremental docking, yielding NylC-HP with enhanced activity and stability. Molecular dynamics simulations gave insight into the effect of substitutions, advancing the understanding of enzymatic PA recycling.

[Research Article]
Hendrik Puetz, Alexander-Maurice Illig, Mariia Vorobii, Christoph Janknecht, Francisca Contreras, Fabian Flemig, Ulrich Schwaneberg
ChemSusChem, https://doi.org/10.1002/cssc.202500257. Read article.