Divergent regioselectivity and diastereoselectivity compared to the wild-type enzyme achieved

Engineering a Decarboxylative Aldolase for the Synthesis of Cyclic Imino Acids

Making Rhodamine B Dyes Using a Continuous Flow Method
Simple catalyst- and solvent-free protocol uses a single-screw mechanochemical approach

Multicomponent Synthesis Combines Spirooxindoles and Dihydropyridines
Catalyst- and solvent-free, microwave-assisted reaction of isatins, β-ketophosphonates, and primary amines

Angewandte Chemie 2/2025: Better Together
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Supramolecular Snub Cubes
The cubes have external diameters of 5.1 nm, contain 2,712 atoms, and chiral cavities with volumes of 6,215 Å

Total Synthesis of Kasugamycin
Aminoglycoside antibiotic prepared from naturally derived carbohydrates

Late-Stage Diazoester Installation
Arylthianthrenium salts used for the introduction of diazo groups to densely functionalized arenes

Site-Selective Hydrogenation of Amides
Copper(I) N-heterocyclic carbene catalyst with an organocatalytic guanidine moiety for amide reduction

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Catalyst-Free N-Acylation of Azoles
Photochemical transformation using aldehydes with inexpensive BrCCl3 as the oxidant