New protocol can be used for the late-stage functionalization of complex, drug-like molecules under mild conditions

Silylation and Germylation of Azauracils

Interstellar Methane as a Progenitor of Amino Acids?
γ-radiation converts methane into glycine and complex molecules, advancing molecular evolution studies and offering a novel methane utilization approach

Practical Path to Dihydrobenzisoxazoles
Partial nitro reduction of methyl 2-nitrobenzoates followed by base-mediated cyclization, alkylation, and reduction gives useful bicyclic compounds
Convergent Path to Bicyclic Boronates
The news covering the work of Peter H. Seeberger, John J. Molloy, and colleagues in Germany was popular last week

Weekly Research News Challenge: Shortest C–I Bond – Simple Synthesis – Multi-Metal Detection
This week's quiz includes questions on the shortest C–I bond, a simple route to bicyclic boronates, and fast multi-metal detection

Twisting Alkyne Cycloparaphenylenes into a Molecular Pinwheel
Strain-promoted alkyne cyclotrimerization gives curved carbon nanostructures

Angewandte Chemie 45/2024: Structures and Applications
Overview of the latest issue of Angewandte Chemie

Crystalline Mesoionic Diazasilole Synthesized
1,4,2-Diazasilole containing a low-valent silicon atom displays characteristics of both a mesoionic silylene and a silylone

Cyanide-Free Synthesis of Thiocyanates and Cyanamides
N-hydroxy-2-oxopropanimidoyl chloride used as an easy-to-handle latent cyanide transfer agent

Cubane Derivatives with Unusually Short Carbon–Halogen Bonds
Hexafluorodihalocubanes feature some exceptionally short bonds, including the shortest C(sp3)–I bond found so far