A three-step pericyclic cascade reaction sequence proves key to synthesizing the core of an insecticidal polyketide

Cascading Towards a Polyketide

Reinvestigating Tatanans A–C
A concise, step-economical synthesis of natural products, tatanans A–C, and their biological activity is examined

Tenure Track: The Royal Road to Professorship?
Wolfgang A. Herrmann, Technical University Munich, Germany, explains how his institution is preparing to attract the best talent

Evolutionary Gel
Adaptable, self-healing supramolecular gels with potential high-tech applications have been produced by UK chemists

Faster-than-Light Travel in 50 Years
50 years until Zefram Cochrane’s test flight of The Phoenix, Earth’s first warp ship; answer to Guess the Chemist 16

Total Synthesis of Gambieric Acids
First total synthesis of potent antifungal polycyclic ether, gambieric acid A, has established its unambiguous structure

Malaria: One Drug, Double Action
The 4(1H)-quinolone derivative ELQ-300 acts against the asymptomatic and symptomatic stages of malaria infection

Vitamin C Goes Astray
Reaction pathways for Maillard degradation of vitamin C are clarified and the end-products identified

New RNA Purine Building Blocks
First synthesis and consequent structure revision of 4'-selenoadenosine and 4'-selenoguanosine, starting from D-ribose

Photocatalytic Oxygenation of Benzene to Phenol
2,3-Dichloro-5,6-dicyano-p-benzoquinone (DDQ) acts as efficient photocatalyst for the one-step oxygenation of benzene to phenol under visible-light irradiation