Designing small-molecule ligands for class B GPCRs despite the lack of structural information for this receptor class

Polyprenylated polycyclic acylphloroglucines which have a range of activities can now be synthesized in just seven steps

Screening existing library of antagonists for binding affinity toward CD22 identifies new potential treatments for B-cell lymphomas

Blocking the expression or activity of a serine protease inhibitor in breast cancer cells could be a potential therapy for breast cancer

Canadian researchers have found a way to eliminate the liabilities of COX-2-specific inhibitors by introducing NO donor groups

An overview of the latest issue of Angewandte Chemie

Italian chemists have devised a quick and cheap route to novel polymeric contrast agents for magnetic resonance imaging (MRI)

The most-accessed chemistry articles from ChemPubSoc Europe and GDCh journals for September 2011

Software screens virtual multi-component reaction products which can be rapidly synthesized and undergo a reality check by physical screening

Comprehensive comparison of hollow-fiber membranes for 129Xe NMR spectroscopy could improve setup