Viral RNA Modifications and Implications for Novel Therapeutics

This online seminar will cover the role of RNA modifications in viral replication, specifically the influenza A virus, and how it might inform the design of both novel antivirals and mRNA-based therapeutics.

Dr. David Courtney, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, will begin this session by elaborating on the importance of RNA modifications and the techniques he and his colleagues have applied for RNA modifications. He will then proceed to describe the varieties of RNA modifications currently known and utilized by RNA viruses during infection of mammalian cells and how molecular virology techniques can elucidate the roles of these modifications. Dr. Courtney will also discuss the previous and latest discovery in cellular systems used to modify viral RNA before concluding on how RNA modification and its future investigations can aid in the design of successful therapeutics.

Highlights

  • Identify which RNA modifications are important for viral replication
  • Reveal how m6A affects influenza virus replication
  • Discuss how viral RNAs are modified
  • Present how RNA modifications might inform future therapeutics
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