A New Class of Anti-AIDS Drugs?

  • Author: Melania Tesio
  • Published: 15 January 2014
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Nature Medicine/Nature Publishing
thumbnail image: A New Class of Anti-AIDS Drugs?

AIDS (acquired immune deficiency syndrome) is a severe disease characterized by a progressive failure of the immune system. It is caused by HIV (immunodeficiency virus), a pathogen that infects immune cells (CD4 T cells) inducing them to die. Although numerous antiviral drugs have been developed, their efficacy is limited as HIV mutates, rendering it resistant to therapies.


By studying the mechanism underlying HIV-induced immune cell death, Warmer Green and co-workers, University of California, San Francisco, CA, USA, identified a potential new class of anti-AIDS therapeutics. The researchers demonstrated that VX-765 (pictured), a well-tolerated inhibitor of the enzyme caspase 1, blocks the destruction of immune cells that occurs during HIV infection.

As VX-765 targets a host protein rather than the HIV virus, it could potentially fight HIV infections without inducing drug resistance.


Article Views: 2681

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH