Tender, Loving Care for Aromatic Amines

  • Author: David Bradley
  • Published: 06 July 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Anal. Methods/RSC
thumbnail image: Tender, Loving Care for Aromatic Amines

Thin-layer chromatography, known affectionately as TLC, can detect primary amines with electron donors using cinnamaldehyde as a reagent on a TLC plate.


Nanomolar detection of aromatic primary amines, used in drug, pesticide, and polymer synthesis, is possible using a TLC plate coated with inexpensive and non-toxic cinnamaldehyde. Colorless amines produce an almost instantaneous yellow spot with a detection limit between 0.02 and 0.28 µg. The test distinguishes between primary amines with an electron donor and those with an electron acceptor which do not cause a color change. Secondary and tertiary amines also give a negative result. The test is a viable alternative to mass spectrometry and chromatography for these important compounds.


Article Views: 2422

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH