In this issue, S. Q. Yao et al. review chemical biology tools for protein lysine acylation. What ligands are capable of targeting regulators of lysine acylation? In a Minireview, F. Emmerling et al. discuss time-resolved in situ monitoring of mechanochemical reactions.

In the original research section, C. He et al. present the enantioselective intermolecular C–H silylation of heteroarenes for the synthesis of acylic Si-stereogenic silanes (see picture). J. N. H. Reek et al. present aqueous biphasic dye-sensitized photosynthesis cells for TEMPO-based oxidation of glycerol. J. Lloret-Fillol et al. succeeded in the photoredox activation of inert alkyl chlorides for reductive cross-coupling with aromatic alkenes. C.-Y. Xu et al. describe bifunctional WC-supported RuO₂ nanoparticles for robust water splitting in acidic media.

• Angewandte Chemie 21/2022: Capabilities,
  Angew. Chem. Int. Ed. 2022, 61 (21).