A novel synthetic macrocycle inhibiting insulin-degrading enzyme shows potent anti-diabetic effects

A New Way to Treat Diabetes?

Probing the Redox Chemistry of Titanium Silicalite-1
New redox reaction of titanium silicalite-1 with triethylaluminum, an indispensable activating agent for olefin polymerization

Alternatives to Animal Testing
How do companies use alternatives to animal testing under the REACH Regulation?

Getting an Enzyme to Like Alcohol
Protein engineering of laccase enhances its stability and activity in the presence of organic alcohol solvents

Synthesis of Aromadendrene and Psiguadial Terpenoids
Bicyclogermacrene as a platform for fast access to a range of different terpenoids

A Funny Control of Heartbeats
Biphenyl urea is a novel tool to pharmacologically control the cardiac activity

2014 Wolf Prize in Chemistry
Professor Chi-Huey Wong, Academia Sinica and The Scripps Research Institute, La Jolla, USA, is this year's winner

Methionine: Find the Right Balance
Methionine-deficient but also -supplemented diet induces deregulation of pivotal molecular pathways in the liver

NDI Tug-of-War!
Push-pull naphthalene diimide (NDI) motifs form the basis of redox molecular switches

Inhibiting Protein Aggregation
Conjugates of 8-hydroxyquinolines and cyclodextrins have been developed that function both as antioxidants and as metal chelators